Non-24-Hour Sleep-Wake Disorder (N24) is a neurological sleep disorder in which a person's sleep/wake cycle is longer than 24 hours. The person is unable to adjust his sleep/wake cycle to the length of the day, and his sleep time progresses around the clock. For example, if he goes to sleep at midnight and sleeps until 8 am one day, he may not be able to fall asleep until 1 or 2 am the next night, and will need to sleep correspondingly later the following morning. The delay does not stop at 1 or 2am but continues to get worse every day until he is going to sleep at 4am, then 6am, 8am, 10am, noon, 2pm etc. Eventually he comes around the clock again to his starting point and the process continues on. For some people the length of their cycle varies from day to day, and they cannot predict their sleep/wake schedule in advance.
Its official designation according to the International Classification of Sleep Disorders (ICSD-2, published in 2005) is Circadian Rhythm Sleep Disorder - Free Running Type. It has also been called Hypernychthemeral Syndrome or simply Free-Running Disorder (FRD).
No. N24 is a neurological sleep disorder. It can cause psychological problems in that it is extremely difficult to cope with the symptoms, and there is often a lack of understanding from family, friends, employers, and even some doctors. It is difficult for most people to understand that abnormal sleep hours may be out of a person's control. The resultant lack of acceptance may seriously undermine the self-esteem and personal relationships of a person with N24.
Many people initially cope with N24 by forcing themselves to keep a normal schedule. This results in a chronic sleep deficit, with symptoms that can mimic depression, attention deficit hyperactivity disorder, chronic fatigue syndrome, fibromyalgia, or just plain fatigue. A patient who complains about not being able to fall asleep may be misdiagnosed with primary insomnia, and prescribed sleep medication. A patient who complains about being tired all the time may be misdiagnosed as suffering from depression, and prescribed antidepressant medication. In some cases, of course, the patient is suffering from depression, but that may be secondary, a result of constant struggle with fatigue or failure at work or school.
N24 people really are unable to fall asleep at the normal time. They cannot shift their faulty body clocks. In medical terms, they are unable to entrain to a normal day/night schedule.
Most N24 people cannot fall asleep earlier no matter how tired they feel. And they've tried.
Many people with N24 sleep very soundly. If they have to get up for work at a time their broken body clock considers night, they may not hear alarm clocks. They may be awakened, with difficulty, only to fall back to sleep again. This is especially true if they have already become sleep deprived.
People with N24 who try to work fixed work hours, such as 9 am to 5 pm, or students who have to attend regular classes, become sleep deprived. This is because, no matter how tired they get, they cannot fall asleep at the same time every night. Yet they still have to get up at the same time in the morning. So they may get little or no sleep during the night and be working at the time their body says they need to sleep. Their work suffers. They may become accident prone. Continuing sleep deprivation affects their health, both physical and mental.
Parents who have N24 may have to be awake early in the morning to feed their kids and get them off to school. Other issues can include difficulty finding and maintaining relationships on such an unusual schedule, shopping when the stores are open, and being awake for appointments with repair people and doctors. These are particularly difficult for people whose day length varies, as they cannot predict in advance when they will be awake.
A more widespread understanding that N24 is a real disability, and a willingness to discuss it in terms which don't blame the individual, would help a great deal. Such understanding would also further efforts to find suitable accommodations.
There are many long-term health effects of sleep deprivation. These can include depression, lowered immune response, anxiety disorders, weight gain, fibromyalgia, diabetes, and cancer.
Many people with N24 feel rested and alert if they can sleep during the hours their bodies require. But others are chronically tired, even if they can sleep as their circadian rhythms dictate. Research suggests that some of their internal systems may be out of sync with others - for example, their digestive system may not be in sync with their sleep/wake system, similar to jet lag.
N24 is quite rare. An incidence of 0.03% has been quoted. N24 occurs primarily among blind individuals, though some sighted persons have the disorder also.
For some, N24 starts in infancy or early childhood. For others, it starts during puberty. Still others start out having Delayed Sleep Phase Syndrome, and progress to N24 as they get older.
A sleep specialist will generally discuss a patient's history and complaints. If a circadian rhythm disorder is suspected, the doctor will require a log of when the patient sleeps and wakes. This may be obtained by monitoring sleep-wake patterns using a wrist activity monitor, a device worn like a wristwatch which tracks movement. The sleep history is most useful if it can be obtained when the patient is sleeping on her natural schedule, without attempting to meet the requirements imposed by work or school. Many patients will have already researched circadian disorders, and come prepared with a sleep log.
Often the sleep doctor will order an overnight polysomnogram (sleep study), to detect or to rule out other disorders such as sleep apnea or PLMD (Periodic Limb Movement Disorder). For people with N24, this test should be performed when the patient can sleep normally, i.e. during the patient's sleep period which may occur at any point during the day. Some doctors will ask for a Multiple Sleep Latency Test (MSLT) to be conducted during the patient's day, to evaluate the possibility of narcolepsy. In some patients, multiple disorders may be present, or another disorder may be the cause of the reported symptoms.
Sleep doctors treat N24 by attempting to entrain the patient to a 24-hour cycle. The patient must first wait until her sleep hours have cycled to the desired time. She is then instructed to use bright light in the morning, and/or the hormone melatonin in the evening, in an attempt to stabilize the body's circadian rhythm at the desired time. This may be effective for some people, but is not for others. Many doctors prescribe medication to help people sleep. This can help some people get to sleep when desired, but often it does not improve the quality of sleep, and the patient remains tired during the day. Many people react to the medications and must stop taking them, and some people find them ineffective.
For many N24s, sleeping on a normal schedule may be difficult or impossible and trying to do so only results in sleep deprivation and stress, with all the harmful health effects that can cause. They find they can be much more productive and much happier living on the rotating schedule to which their body naturally reverts. For people with severe cases, this may be the only realistic option.
For those for whom treatment is ineffective, N24 can make it impossible to maintain a fixed work or school schedule. For those who have jobs requiring a fixed schedule, as well as students who are required to attend regular classes, if treatment fails, N24 is a disability. Schools and employers in the U.S. are required, under the Americans with Disabilities Act, to provide reasonable accommodations, including part-time or modified work schedules. Sleep disorders qualify students for a Section 504 plan. Consult a lawyer for details. Other countries may have similar requirements for accommodation.
Allowing greater flexibility in work hours. Allowing workers to work from home, at the times they can. Permitting shorter work hours, at correspondingly lower pay, for those that need this because of chronic tiredness. For students, allowing them to take courses given at non-standard times, or recorded on video, or online; or recognizing that they may miss some classes, but may be able to keep up with the coursework nonetheless. Providing for exams to be given at an appropriate time. Allowing a lighter course load, even if this means delaying graduation.
N24 does not affect intelligence. But study, concentration, memory, and attention span are affected by sleepiness. Adjustments in study habits may be necessary. This can best be accomplished with the cooperation of school personnel. It is important to identify children with N24 at the earliest possible age to prevent a pattern of failure from developing, thus fostering low self-esteem.
There is, of course, work being done on the basic nature and function of sleep, which is still not really understood. There is ongoing research on the genetic, neurological, and chemical pathways involved in the circadian clock. Studies have been done with animals, and in some cases with normal human subjects, but seldom with N24 patients. There is continuing research on the effects of light and melatonin on the circadian rhythm, and other possible interventions, including with N24 subjects.
Circadian Sleep Disorders Network is a 501(c)(3) nonprofit organization promoting awareness, accommodation, support, and research around the issues of Circadian Rhythm Sleep Disorders. Please see our web site, www.circadiansleepdisorders.org (shortcut: csd-n.org) for details, for more information about these disorders, and to print this and similar documents, which may be freely distributed. And please join if you or your child is among those affected by N24!